This article provides a comprehensive history of the discovery of sickle cell disease and the currently available treatments. As the research is actively pursuing gene therapy the long standing concerns about health care costs is becoming an ever increasing concern. Gene therapy is expensive and not yet proven as a cure. The research continues on a path to prove durability. The article discusses the issues identified in the research done by both Vertex and Bluebird Bio – interesting background as we usually just get the headlines here.

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